Coutts R T, Baker G B, Malek F, Hussain M S
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
Res Commun Chem Pathol Pharmacol. 1991 Oct;74(1):15-24.
Prior administration of quinidine is known to reduce aromatic oxidation of amphetamine and its analog methoxyphenamine by inhibiting the cytochrome P450IID6 results in isozyme. In contrast, it is now shown that prior administration of quinidine results in a significant increase in the aromatic oxidation of N-n-butylamphetamine in rat, suggesting that the P450IID6 isozyme is not involved in this metabolic reaction.
已知预先给予奎尼丁会通过抑制细胞色素P450IID6同工酶来降低苯丙胺及其类似物甲氧苯丙胺的芳香族氧化。相比之下，现在表明预先给予奎尼丁会导致大鼠体内N-正丁基苯丙胺的芳香族氧化显著增加，这表明P450IID6同工酶不参与这种代谢反应。
