Uwaydah A K, Matar I, Chacko K C, Davidson J C
Department of Internal Medicine, Hamad General Hospital, Doha, Quatare.
Trans R Soc Trop Med Hyg. 1991 Nov-Dec;85(6):790-2. doi: 10.1016/0035-9203(91)90457-a.
Multiresistant Salmonella seems to be a growing problem in Qatar and its treatment remains problematic. Of 100 Salmonella bacteraemias that occurred between 1 October 1989 and 30 September 1990, 30 were caused by S. typhi resistant to one or more of the conventional antibiotics usually recommended for the treatment of typhoid fever (ampicillin, chloramphenicol, and trimethoprim-sulphamethoxazole). Of those, 25 (83%) were acquired by patients during visits to the Indian subcontinent. Two patients with isolates sensitive to ampicillin were successfully treated with amoxicillin, 6 paediatric patients were cured with cefotaxime, and 20 adult patients responded favourable to ciprofloxacin. A 9 year old boy failed initial therapy with cefuroxime but responded well to ciprofloxacin. One adult patient was treated successfully with a combination of ciprofloxacin and cefotaxime. We conclude that cefotaxime and ciprofloxacin can serve as first line therapy for typhoid fever in areas where multi-resistant Salmonella is prevalent.
多重耐药沙门氏菌似乎在卡塔尔成为一个日益严重的问题，其治疗仍然存在困难。在1989年10月1日至1990年9月30日期间发生的100例沙门氏菌血症中，30例是由对一种或多种通常推荐用于治疗伤寒热的传统抗生素（氨苄青霉素、氯霉素和甲氧苄啶-磺胺甲恶唑）耐药的伤寒沙门氏菌引起的。其中，25例（83%）是患者在访问印度次大陆期间感染的。2例对氨苄青霉素敏感的分离株患者用阿莫西林成功治疗，6例儿科患者用头孢噻肟治愈，20例成年患者对环丙沙星反应良好。一名9岁男孩最初用头孢呋辛治疗失败，但对环丙沙星反应良好。一名成年患者用环丙沙星和头孢噻肟联合治疗成功。我们得出结论，在多重耐药沙门氏菌流行的地区，头孢噻肟和环丙沙星可作为伤寒热的一线治疗药物。
