Vrzheshch P V
Vestn Akad Med Nauk SSSR. 1991(10):57-63.
The author proposes a functional model of the cell as a set of the simplest functional blocks each of which consists of a cellular signal receptor, a system of signal transmission in the chain of secondary intermediaries and an element whose numerical value characterizes the cellular response. The steady-state approximation of the dependence of the cellular response on the concentration of an activator and inhibitors was analyzed quantitatively and qualitatively. Mathematic criteria for the existence were defined. Analysis was made of the properties of the maximal signal enhancement mode, of the signal enhancement lack mode, and of the intermediate and bifurcation modes. Equations were derived, connecting the experimentally observed parameters of the concentration dependencies with the parameters of the simplest functional blocks.
作者提出了一种细胞功能模型，将其视为一组最简单的功能模块，每个模块都由一个细胞信号受体、一个二级中介链中的信号传输系统以及一个其数值表征细胞反应的元件组成。对细胞反应对激活剂和抑制剂浓度依赖性的稳态近似进行了定量和定性分析。定义了存在的数学标准。分析了最大信号增强模式、信号增强缺失模式、中间模式和分岔模式的特性。推导了将实验观察到的浓度依赖性参数与最简单功能模块的参数联系起来的方程。
