Verkhusha V V, Vrzheshch P V, Varfolomeev S D
Vestn Akad Med Nauk SSSR. 1991(10):20-8.
A study was made of a model of platelet aggregation in shear flow taking into account the kinetics of intercellular fibrinogen bond formation limited by the turning time of the doublet of collided platelets. The energy curve for two platelets was calculated. One fibrinogen bond was sufficient to form a doublet stable in the flow. The equation for the rate of single platelet disappearance with regard to the kinetics of intercellular fibrinogen bond formation, the stochastic character of bond distribution on the contacts of collided platelets, hydrodynamically controlled time of their interaction was derived. Approximation of the obtained dependencies for the platelet aggregation rate by Hill's equation was suggested and its parameters were determined. A qualitative criterion for kinetic behavior of the system of aggregating platelets was introduced.
对剪切流中血小板聚集模型进行了研究，该模型考虑了受碰撞血小板双联体转动时间限制的细胞间纤维蛋白原键形成动力学。计算了两个血小板的能量曲线。一个纤维蛋白原键足以形成在流中稳定的双联体。推导了关于细胞间纤维蛋白原键形成动力学、碰撞血小板接触处键分布的随机特性、流体动力学控制的它们相互作用时间的单个血小板消失速率方程。提出了用希尔方程对所得血小板聚集速率相关性进行近似，并确定了其参数。引入了聚集血小板系统动力学行为的定性标准。
