Krieter H, Frey L, Segiet W, Brückner U B, Krumwieh D, Seiler F R, Messmer K
Department of Experimental Surgery, University of Heidelberg, Germany.
Behring Inst Mitt. 1991 Dec(90):75-85.
The transfusion of autologous blood protects surgical patients from both the transfusion transmitted diseases (AIDS, posttransfusion hepatitis) and the immunosuppressive effects of homologous blood. Nevertheless, the use of autologous blood is still unsatisfactory, mainly because of the elaborated logistics, organization and technique required and the often insufficient amounts of autologous blood gained. Today, the major growth-factors of erythropoiesis are available as recombinant analogues. In the studies reviewed here, we investigated the effects of rhu-EPO and IL-3 on perioperative erythropoiesis in two canine models of acute isovolemic hemodilution. Different therapeutic concepts are compared with respect to preoperative changes in hematocrit, the volume of autologous blood gained and the duration of postdilutional anemia.
自体输血可保护外科手术患者免受输血传播疾病（艾滋病、输血后肝炎）以及异体血免疫抑制作用的影响。然而，自体血的使用仍不尽人意，主要是因为所需的复杂后勤、组织和技术，以及获得的自体血量往往不足。如今，主要的红细胞生成生长因子已有重组类似物。在本文所综述的研究中，我们在两种急性等容性血液稀释犬模型中研究了重组人促红细胞生成素（rhu-EPO）和白细胞介素-3（IL-3）对围手术期红细胞生成的影响。就术前血细胞比容的变化、获得的自体血量以及稀释后贫血的持续时间而言，对不同的治疗方案进行了比较。
