Nitschko H, Schätzl H, Gelderblom H R, Oswald M, von der Helm K
Max-von-Pettenkofer Institute, University of Munich, FRG.
Biomed Biochim Acta. 1991;50(4-6):655-8.
Newly developed inhibitors block the aspartic-type retroviral proteinase of the human immunodeficiency virus (HIV) at nanomolar concentration. The viral proteinase is responsible for the processing of viral encoded proteins. Applied to HIV infected cell culture, these inhibitors exhibit antiviral effects. The detailed analysis of these antiviral effects demonstrated that the synthesis of viral particles is only minimally decreased while the rate of infectious HIV particles is substantially reduced. The lack of infectivity is due to a failure in particle maturation which again is caused by the inhibition of the viral proteinase.
新开发的抑制剂能在纳摩尔浓度下阻断人类免疫缺陷病毒（HIV）的天冬氨酸型逆转录病毒蛋白酶。病毒蛋白酶负责处理病毒编码的蛋白质。将这些抑制剂应用于HIV感染的细胞培养物中，它们表现出抗病毒作用。对这些抗病毒作用的详细分析表明，病毒颗粒的合成仅略有减少，而具有感染性的HIV颗粒的比率则大幅降低。缺乏感染性是由于颗粒成熟失败，而这又是由病毒蛋白酶的抑制引起的。
