Gelpi Ellen, Preusser Matthias, Czech Thomas, Slavc Irene, Prayer Daniela, Budka Herbert
Institute of Neurology, Medical University of Vienna, Vienna, Austria.
Neuropathology. 2007 Oct;27(5):468-73. doi: 10.1111/j.1440-1789.2007.00802.x.
Papillary glioneuronal tumor (PGNT) is a rare, recently recognized tumor type histologically characterized by pseudopapillary architecture associated with compact areas composed of neuronal elements in different maturation states. The histogenesis of this tumor type is still unclear. The immunophenotype of PGNT comprises expression of several glial and neuronal proteins. Recently, immunohistochemical expression of Olig2 in a fraction of tumor cells has been reported, suggesting an additional oligodendroglial or at least oligodendroglia-like tumor cell component. We report a further case of papillary glioneuronal tumor in a 12-year-old boy with immunohistochemical expression of PDGFRalpha, Olig2 and Nestin in support of a postulated origin of this tumor type from common progenitor cells in the subependymal plate. Nevertheless, further studies are needed to clarify the histogenesis of PGNT.
乳头状胶质神经元肿瘤（PGNT）是一种罕见的、最近才被认识的肿瘤类型，其组织学特征为假乳头状结构，伴有由处于不同成熟状态的神经元成分组成的致密区域。这种肿瘤类型的组织发生仍不清楚。PGNT的免疫表型包括几种胶质和神经元蛋白的表达。最近，有报道称部分肿瘤细胞中Olig2呈免疫组化表达，提示存在额外的少突胶质细胞或至少类似少突胶质细胞的肿瘤细胞成分。我们报告了一例12岁男孩的乳头状胶质神经元肿瘤，其PDGFRα、Olig2和Nestin呈免疫组化表达，支持该肿瘤类型起源于室管膜下板共同祖细胞的假设。然而，仍需要进一步研究来阐明PGNT的组织发生。
