乳头状胶质神经元肿瘤——具有双表型分化的干细胞起源证据

Papillary glioneuronal tumor-evidence of stem cell origin with biphenotypic differentiation.

作者信息

Govindan Aparna, Mahadevan A, Bhat D I, Arivazhagan A, Chakraborti Shrijeet, Suja M S, Phalguni A A, Sampath S, Chandramouli B A, Shankar S K

机构信息

Department of Neuropathology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.

Department of Neurosurgery, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.

出版信息

J Neurooncol. 2009 Oct;95(1):71-80. doi: 10.1007/s11060-009-9893-5. Epub 2009 Apr 30.

DOI:10.1007/s11060-009-9893-5

PMID:19404583

Abstract

Papillary glioneuronal tumors are newly recognized seizure producing tumors. We report two such cases with immunohistochemical characterization of glial and neuronal components and briefly review literature. Co-localization of glial and neuronal markers was demonstrable on confocal microscopy with expression of stem cell markers (Nestin and CD133) suggesting possible origin from neuroepithelial stem cell with biphenotypic differentiation.

摘要

乳头状胶质神经元肿瘤是新发现的可导致癫痫发作的肿瘤。我们报告两例此类病例，并对其胶质和神经元成分进行免疫组化特征分析，同时简要回顾文献。在共聚焦显微镜下可证实胶质和神经元标志物的共定位，同时干细胞标志物（巢蛋白和CD133）表达，提示其可能起源于具有双表型分化的神经上皮干细胞。