Olig基因家族在脑癌中的生物学功能及治疗靶点

Szu Jenny I, Tsigelny Igor F, Wojcinski Alexander, Kesari Santosh

Department of Translational Neurosciences, Providence Saint John's Health Center, Saint John's Cancer Institute, Santa Monica, CA, United States.

San Diego Supercomputer Center, University of California, San Diego, San Diego, CA, United States.

Front Neurosci. 2023 May 18;17:1129434. doi: 10.3389/fnins.2023.1129434. eCollection 2023.

The genes encode members of the basic helix-loop-helix (bHLH) family of transcription factors. Olig1, Olig2, and Olig3 are expressed in both the developing and mature central nervous system (CNS) and regulate cellular specification and differentiation. Over the past decade extensive studies have established functional roles of and in development as well as in cancer. Olig2 overexpression drives glioma proliferation and resistance to radiation and chemotherapy. In this review, we summarize the biological functions of the Olig family in brain cancer and how targeting Olig family genes may have therapeutic benefit.

这些基因编码转录因子基本螺旋-环-螺旋（bHLH）家族的成员。Olig1、Olig2和Olig3在发育中的和成熟的中枢神经系统（CNS）中均有表达，并调节细胞的特化和分化。在过去十年中，广泛的研究已确定了它们在发育以及癌症中的功能作用。Olig2的过表达会驱动胶质瘤增殖以及对放疗和化疗产生抗性。在本综述中，我们总结了Olig家族在脑癌中的生物学功能，以及靶向Olig家族基因可能具有的治疗益处。