Kakudo Kennichi, Bai Yanhua, Li Yaqiong, Wakasa Tomoko, Mori Ichiro
Department of Pathology, Wakayama Medical University.
Nihon Rinsho. 2007 Nov;65(11):1979-84.
The poorly differentiated carcinoma was first added as a new member in the lists of classification of thyroid carcinomas in the WHO 2004 edition. However its histological criteria include necrosis and increased mitoses in addition to the original definition by Sakamoto's proposal, solid, trabecular and schirrhous growth. This modification creates a significant change in the incidence and prognosis of this carcinoma. This carcinoma, defined by the new WHO classification, is about 1-5% of all thyroid malignancy and has more aggressive outcome than the previous definition.
低分化癌于2004年版世界卫生组织甲状腺癌分类列表中首次作为新成员被纳入。然而，其组织学标准除了包括坂本提议的原始定义（实性、小梁状和硬癌生长方式）外，还包括坏死和有丝分裂增加。这一修改使得该癌的发病率和预后发生了显著变化。根据世界卫生组织新分类定义的这种癌约占所有甲状腺恶性肿瘤的1%-5%，并且比之前的定义具有更侵袭性的预后。
