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Is the antianginal action of trimetazidine independent of hemodynamic changes?

作者信息

Timour Q, Harpey C, Durr F, Faucon G

出版信息

Cardiovasc Drugs Ther. 1991 Dec;5(6):1043-4. doi: 10.1007/BF00143533.

DOI:10.1007/BF00143533
PMID:1801891
Abstract
摘要

相似文献

1
Is the antianginal action of trimetazidine independent of hemodynamic changes?曲美他嗪的抗心绞痛作用是否独立于血流动力学变化？
Cardiovasc Drugs Ther. 1991 Dec;5(6):1043-4. doi: 10.1007/BF00143533.
2
Trimetazidine. A review of its use in stable angina pectoris and other coronary conditions.曲美他嗪。关于其在稳定型心绞痛及其他冠状动脉疾病中应用的综述。
Drugs. 1999 Jul;58(1):143-57. doi: 10.2165/00003495-199958010-00016.
3
Assessment of anti-ischemic and antianginal effect at trough plasma concentration and safety of trimetazidine MR 35 mg in patients with stable angina pectoris: a multicenter, double-blind, placebo-controlled study.评估曲美他嗪缓释片35mg在稳定型心绞痛患者谷浓度时的抗缺血和抗心绞痛作用及安全性：一项多中心、双盲、安慰剂对照研究。
Am J Cardiovasc Drugs. 2003;3(5):361-9. doi: 10.2165/00129784-200303050-00007.
4
Treatment of stable angina pectoris with trimetazidine modified release in Indian primary-care practice.在印度基层医疗实践中使用曲美他嗪缓释片治疗稳定型心绞痛。
Am J Cardiovasc Drugs. 2005;5(5):325-9. doi: 10.2165/00129784-200505050-00005.
5
[The effects of trimetazidine on ergometric parameters in exercise-induced angina. Controlled multicenter double blind versus placebo study].
Arch Mal Coeur Vaiss. 1986 Aug;79(9):1331-6.
6
[Efficacy and tolerance of trimetazidine, a metabolic antianginal, in combination with a hemodynamic antianginal in stable exertion angina. TRIMPOL I, a multicenter study].代谢型抗心绞痛药物曲美他嗪与血流动力学抗心绞痛药物联合应用于稳定型劳力性心绞痛的疗效及耐受性。TRIMPOL I多中心研究
Presse Med. 2000 Mar 18;29(10):533-8.
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The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.抗心绞痛药物曲美他嗪通过抑制线粒体长链3-酮酰基辅酶A硫解酶，将心脏能量代谢从脂肪酸氧化转变为葡萄糖氧化。
Circ Res. 2000 Mar 17;86(5):580-8. doi: 10.1161/01.res.86.5.580.
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[Trimetazidine in the treatment of stable angina pectoris TRIADA-(trimetazidine in stable angina twice daily)].曲美他嗪治疗稳定型心绞痛TRIADA研究（曲美他嗪治疗稳定型心绞痛每日两次）
Vnitr Lek. 2006 Jun;52(6):609-14.
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Antianginal effects of trimetazidine and left ventricular function improvement in patients with stable angina pectoris.曲美他嗪对稳定型心绞痛患者的抗心绞痛作用及左心室功能改善情况
Am J Cardiovasc Drugs. 2002;2(2):119-24. doi: 10.2165/00129784-200202020-00005.
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Combination of trimetazidine with nifedipine in effort angina.曲美他嗪与硝苯地平联合用于劳力型心绞痛
Cardiovasc Drugs Ther. 1990 Aug;4 Suppl 4:824-5. doi: 10.1007/BF00051287.

引用本文的文献

1
Trimetazidine. A review of its use in stable angina pectoris and other coronary conditions.曲美他嗪。关于其在稳定型心绞痛及其他冠状动脉疾病中应用的综述。
Drugs. 1999 Jul;58(1):143-57. doi: 10.2165/00003495-199958010-00016.
2
Intracoronary trimetazidine does not improve recovery of regional function in a porcine model of repeated ischemia.
Cardiovasc Drugs Ther. 1993 Nov;7(5):801-7. doi: 10.1007/BF00878934.

本文引用的文献

1
Differential effects of nitroglycerin, trimetazidine, verapamil and SK&F 24260 on venous return as revealed by the open-loop method in the dog.
Jpn J Pharmacol. 1980 Aug;30(4):449-61. doi: 10.1254/jjp.30.449.
2
Acute effects of trimetazidine evaluated by exercise testing.通过运动试验评估曲美他嗪的急性效应。
Eur J Clin Pharmacol. 1987;33(2):205-7. doi: 10.1007/BF00544569.