Sellier P, Audouin P, Payen B, Corona P, Duong T C, Ourbak P
Department of Cardiology, Hôpital Broussais, Paris, France.
Eur J Clin Pharmacol. 1987;33(2):205-7. doi: 10.1007/BF00544569.
A single dose of 60 mg trimetazidine (the normal daily dose) improved exercise capacity in angina pectoris, as reflected by an increase in the duration of exercise, total work performed, and improvement in ECG signs of ischaemia. All these effects occurred without any detectable chronotropic or vasomotor effect. The importance of this study is to demonstrate that these beneficial effects, already well-recognized after chronic administration of 20 mg three times a day, also occur after a single administration equivalent to the normal daily dose.
单剂量60毫克曲美他嗪（正常日剂量）可改善心绞痛患者的运动能力，表现为运动持续时间增加、总做功量提高以及缺血性心电图体征改善。所有这些效应出现时均未检测到任何变时性或血管舒缩效应。本研究的重要意义在于证明，这些在每日三次服用20毫克进行长期给药后已得到充分认可的有益效应，在单次给予相当于正常日剂量的药物后同样会出现。
