Sarlani Eleni, Garrett Pauline H, Grace Edward G, Greenspan Joel D
Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland, USA.
J Orofac Pain. 2007 Fall;21(4):309-17.
To examine differences in temporal summation of mechanically evoked pain between women and men suffering from chronic pain associated with temporomandibular disorders (TMD), as well as between male TMD patients and healthy controls.
Series of 10 repetitive, mildly noxious mechanical stimuli were applied to the fingers of 27 female TMD patients, 16 male TMD patients, and 20 healthy men. The subjects rated the pain intensity caused by the 1st, 5th, and 10th stimulus in the series. Pain ratings were analyzed by 3-way repeated-measures analysis of variance.
Pain ratings increased significantly with stimulus repetition for the female TMD patients (P < .001). Women with TMD exhibited significantly greater temporal summation of pain than TMD men (P < .001). Neither the healthy men nor the male TMD patients exhibited significant increases in pain perception with repetitive stimulation. In the female TMD patient group, perceptual pain magnitudes were higher with an interstimulus interval of 2 seconds rather than 10 seconds (P < .005).
These findings suggest that central nociceptive processing upregulation is likely to contribute to TMD pain for women but is not a factor for
研究患有颞下颌关节紊乱病（TMD）的慢性疼痛女性和男性之间，以及男性TMD患者与健康对照者之间机械诱发疼痛的时间总和差异。
对27名女性TMD患者、16名男性TMD患者和20名健康男性的手指施加一系列10次重复性轻度有害机械刺激。受试者对系列中第1次、第5次和第10次刺激所引起的疼痛强度进行评分。疼痛评分通过三因素重复测量方差分析进行分析。
女性TMD患者的疼痛评分随刺激重复显著增加（P < .001）。患有TMD的女性比男性TMD患者表现出明显更大的疼痛时间总和（P < .001）。健康男性和男性TMD患者在重复刺激时疼痛感知均未显著增加。在女性TMD患者组中，刺激间隔为2秒时的疼痛感知强度高于10秒时（P < .005）。
这些发现表明，中枢伤害性处理上调可能是女性TMD疼痛的一个因素，但不是男性TMD疼痛的因素 。 （注：原文最后一句不完整，翻译时根据前文推测补充完整了大概意思）
