O'Sullivan Timothy P, Zhang Hongbin, Mander Lewis N
Department of Chemistry, University College Cork, Cork, Ireland.
Org Biomol Chem. 2007 Aug 21;5(16):2627-35. doi: 10.1039/b707467k.
In model studies towards the synthesis of harringtonolide, the construction of the tropone moiety via arene cyclopropanation was investigated. The installation of the lactone ring was accomplished by way of a Diels-Alder cycloaddition of various indenones and a-pyones. The incorporation of the key bridge methyl group and subsequent control of its stereochemistry is also outlined.
在对海南粗榧内酯合成的模型研究中，研究了通过芳烃环丙烷化构建卓酚酮部分。内酯环的安装是通过各种茚满酮与α-吡喃酮的狄尔斯-阿尔德环加成反应完成的。还概述了关键桥甲基的引入及其立体化学的后续控制。
