Kanda Tatsuo, Yokosuka Osamu, Imazeki Fumio, Hirasawa Yuichi, Ikeuchi Tetsu, Mikata Rintaro, Zhang Kai Y, Kurihara Tomoko, Arai Makoto, Fukai Kenichi, Saisho Hiromitsu, Mikami Shigeru, Azemoto Ryosaku, Ito Yoshimi
Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan.
Hepatogastroenterology. 2007 Sep;54(78):1758-60.
BACKGROUND/AIMS: The aim of this study was to investigate the effects of being overweight on autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) patients.
METHODOLOGY/RESULTS: 44 AIH and 95 PBC patients were enrolled in this study. Body weight and body mass index (BMI) of AIH (57.6 +/- 10.4 kg and 23.8 +/- 2.9 kgm(-2), respectively) were higher than those of PBC (51.6 +/- 7.0 kg and 22.0 +/- 2.6 kgm(-2), respectively) (P < 0.001). The prevalence of overweight patients in AIH was also higher than those in PBC (P < 0.005). Being overweight and having 25 < or = BMI < 30 did not affect the progression of hepatic fibrosis in AIH and PBC. In comparison with the non-overweight with PBC, overweight patients with PBC tended not to be symptomatic, such as having itching or fatigue (P = 0.027).
Clinicians should be aware that not only non-alcoholic fatty liver disease but also PBC patients might be included among the overweight hepatic disease patients with unknown etiology.
背景/目的：本研究旨在调查超重对自身免疫性肝炎（AIH）和原发性胆汁性肝硬化（PBC）患者的影响。
方法/结果：本研究纳入了44例AIH患者和95例PBC患者。AIH患者的体重和体重指数（BMI）（分别为57.6±10.4 kg和23.8±2.9 kg/m²）高于PBC患者（分别为51.6±7.0 kg和22.0±2.6 kg/m²）（P<0.001）。AIH患者中超重患者的比例也高于PBC患者（P<0.005）。超重以及BMI在25≤BMI<30范围内对AIH和PBC患者肝纤维化的进展没有影响。与非超重的PBC患者相比，超重的PBC患者往往没有诸如瘙痒或疲劳等症状（P = 0.027）。
临床医生应意识到，病因不明的超重肝病患者中不仅可能包括非酒精性脂肪性肝病患者，还可能包括PBC患者。
