接受α干扰素治疗的慢性病毒性肝炎患者的抗血小板抗体

Antiplatelet antibodies in patients with chronic viral hepatitis receiving interferon-alpha.

作者信息

Christodoulou Dimitrios, Christou Leonidas, Zervou Eleftheria, Katsanos Konstantinos, Kitsanou Margarita, Tsianos Epameinondas V

机构信息

1st Department of Internal Medicine, Hepato-Gastroenterology Unit, Medical School, University of Ioannina, Greece.

出版信息

Hepatogastroenterology. 2007 Sep;54(78):1761-5.

PMID:18019713

Abstract

BACKGROUND/AIMS: The aim of this study was to investigate the possible role of interferon-alpha in the development of antiplatelet IgG antibodies in patients with chronic viral hepatitis B or C.

METHODOLOGY

Ninety-one consecutive patients with chronic viral hepatitis (51 with chronic hepatitis B and 40 with chronic hepatitis C) were investigated for the presence of antiplatelet IgG antibodies in their serum immediately prior to IFN-alpha therapy and after six months of therapy. The method used was the solid phase red cell adherence test (Immucor, Norcross, USA), which is a sensitive tracer of antiplatelet antibodies. Some of the results were confirmed using an indirect immunofluorescence test for the detection of antiplatelet antibodies

RESULTS

Overall, we found that antiplatelet antibodies were present in 37.54% (19/51) of patients with chronic hepatitis B before IFN-alpha therapy and in 35.29% (18/51) after therapy. Moreover, antiplatelet antibodies were found in 20% (8/40) of patients with chronic hepatitis C before and after IFN-alpha therapy.

CONCLUSIONS

Therapy with IFN-alpha did not induce antiplatelet antibodies in patients with chronic viral hepatitis B or C. Thrombocytopenia observed during IFN-alpha therapy in our study was not due to the development of antiplatelet antibodies.

摘要

背景/目的：本研究旨在探讨α干扰素在慢性乙型或丙型病毒性肝炎患者抗血小板IgG抗体产生过程中可能发挥的作用。

方法

对91例连续的慢性病毒性肝炎患者（51例慢性乙型肝炎患者和40例慢性丙型肝炎患者）在α干扰素治疗前及治疗6个月后检测其血清中抗血小板IgG抗体。采用的方法是固相红细胞粘附试验（美国诺克罗斯Immucor公司产品），这是一种检测抗血小板抗体的敏感方法。部分结果通过间接免疫荧光试验检测抗血小板抗体得以证实。