Swiatkowska-Stodulska Renata, Dejneka Wojciech, Jabłońska-Kaszewska Irena, Lukasiak Jerzy, Kiszkis Hanna, Wiśniewski Piotr, Lubińska Monika, Sworczak Krzysztof
Department of Internal Medicine, Endocrinology and Hemostatic Disorders, Medical University of Gdańsk, Poland.
Hepatogastroenterology. 2007 Sep;54(78):1788-90.
BACKGROUND/AIMS: Wilson's disease is a genetically determined disorder of copper metabolism in the liver. Due to the toxic accumulation of this trace element, body organs are damaged by free radical generation, lipid peroxidase and inhibition of synthesis of some proteins. Behavior of anti-oxidative factors in Wilson's disease has not been completely evaluated yet. The aim of the study was to assess blood serum concentrations of selenium in patients with Wilson's disease.
Twenty-five patients with Wilson's disease and 30 healthy volunteers, constituting a control group were included in the study. The patients were in good clinical condition. In all the subjects blood serum concentrations of selenium were tested using the atomic absorption spectroscopy, hydride generation method.
Selenium concentrations in the blood serum of the patients and healthy controls did not show statistical differences between both groups. Correlations between selenium concentrations and biochemical parameters: activity of alanine and aspartate aminotransferase, alkaline phosphatase, gamma-glutamyltranspeptidase, concentration of bilirubin, albumin and gamma globulin, international normalized prothrombin index as well as serum copper, ceruloplasmine and 24-h urine copper excretion were assessed. Statistically significant correlation was found only between selenium concentration and aspartate aminotransferase activity. No statistically significant differences between selenium concentrations in the serum of patients with different forms of Wilson's disease were found.
On the basis of the results obtained in the study it can be assumed that in treated patients with Wilson's disease the antioxidant status measured as serum selenium concentration is comparable to healthy controls.
背景/目的：威尔逊氏病是一种由基因决定的肝脏铜代谢紊乱疾病。由于这种微量元素的毒性积累，机体器官会因自由基生成、脂质过氧化以及某些蛋白质合成受抑制而受损。威尔逊氏病中抗氧化因子的行为尚未得到全面评估。本研究的目的是评估威尔逊氏病患者血清中的硒浓度。
本研究纳入了25例威尔逊氏病患者和30名健康志愿者作为对照组。患者临床状况良好。所有受试者均采用原子吸收光谱法、氢化物发生法检测血清中的硒浓度。
患者血清和健康对照组的硒浓度在两组之间未显示出统计学差异。评估了硒浓度与生化参数之间的相关性：丙氨酸和天冬氨酸转氨酶活性、碱性磷酸酶、γ-谷氨酰转肽酶、胆红素浓度、白蛋白和γ球蛋白、国际标准化凝血酶原指数以及血清铜、铜蓝蛋白和24小时尿铜排泄量。仅发现硒浓度与天冬氨酸转氨酶活性之间存在统计学显著相关性。不同形式威尔逊氏病患者血清中的硒浓度未发现统计学显著差异。
根据本研究获得的结果，可以假设在接受治疗的威尔逊氏病患者中，以血清硒浓度衡量的抗氧化状态与健康对照组相当。
