对威尔逊病患者和正常受试者血液及尿液中铜浓度数据的贡献。

Contribution to the data on copper concentration in blood and urine in patients with Wilson's disease and in normal subjects.

作者信息

Lech T, Sadlik J K

机构信息

Institute of Forensic Research, ul. Westerplatte 9, Kraków, 31-033, Poland.

出版信息

Biol Trace Elem Res. 2007 Jul;118(1):16-20. doi: 10.1007/s12011-007-0015-y.

DOI:10.1007/s12011-007-0015-y

PMID:17848726

Abstract

Determination of copper in human tissues and body fluids may be crucial in the diagnosis of Wilson's disease. In this study we evaluated urinary copper excretion and urine and blood concentration in 14 patients in whom Wilson's disease was confirmed (group A) and in 21 subjects in whom the disease was only suspected (group B). The following values (mean +/- SD) were found: 24-h urine (microg Cu/24 h), 152 +/- 135 (A) and 31.8 +/- 10.9 (B); urine (microg Cu/ml), 0.091 +/- 0.087 (A) and 0.028 +/- 0.011 (B); and blood (microg Cu/ml), 0.62 +/- 0.25 (A) and 0.72 +/- 0.09 (B). By comparison, urine copper concentration in the group of apparently healthy subjects was 0.035 +/- 0.010 (n = 50), and blood copper concentration in autopsy cases of nonpoisoned people was 0.85 +/- 0.19 (n = 73).

摘要

测定人体组织和体液中的铜含量对于威尔逊氏病的诊断可能至关重要。在本研究中，我们评估了14例确诊为威尔逊氏病的患者（A组）和21例仅疑似患有该病的受试者（B组）的尿铜排泄量以及尿液和血液中的铜浓度。结果发现以下数值（平均值±标准差）：24小时尿铜（μg Cu/24小时），152±135（A组）和31.8±10.9（B组）；尿铜（μg Cu/ml），0.091±0.087（A组）和0.028±0.011（B组）；以及血铜（μg Cu/ml），0.62±0.25（A组）和0.72±0.09（B组）。相比之下，明显健康受试者组的尿铜浓度为0.035±0.010（n = 50），未中毒者尸检病例的血铜浓度为0.85±0.19（n = 73）。