Urothelial bladder biopsy--important evolution prognosis factor of superficial bladder cancer under intravesical Bacille Calmette-Guérin therapy.

During 11 years we investigated the value of multiple randomised biopsies (4 quadrant) and by in vivo staining with methylene blue (chromocystoscopy) of 231 cases with superficial bladder tumours under complementary intravesical Bacille Calmette-Guérin therapy (3 years of immunotherapic treatment after our protocol). We discovered the appearance of 20 cases with carcinoma insitu (Cis) and 105 cases with different degrees of dysplasia (simple, medium and severe). We demonstrated 69.44% pathological bladder biopsies on normal-looking mucosa. 75% of the recurrent tumours (44 cases-22.44%) had pathological bladder urothel al field modifications associated with bladder cancer. On this occasion, we point out the highest prognostic value of the complex protocol of superficial bladder tumour evaluation based on the study of the bladder biopsies as an essential parameter.