Geavlete P, Taşcă C
University Department of Urology, Clinical Hospital Saint John, Bucharest, Romania.
Rom J Morphol Embryol. 1991 Jan-Jun;37(1-2):69-74.
We analysed the evolution of 33 cases with carcinoma in situ (Cis) of the urinary bladder using the intravesical Bacille Calmette-Guérin (BCG) therapy (2 cases with primary Cis, 20 cases discovered at 4 quadrant biopsies within surgical treatment of superficial bladder tumours and 5 cases discovered at 3 monthly evaluation cystoscopy and chromocystoscopy). The mean period of follow-up was 40 months. Our protocol of immunotherapy was maintained for 3 years (8 weekly instillations with 100 mg Romanian--modified Pasteur BCG vaccine in 50 ml of saline, followed by monthly instillations for 10 months and then 3 monthly instillations for 2 years with the same doses). We described the great importance of this "long-course treatment": 12 cases with persistent Cis after 6 months and 2 cases with persistent Cis after 21 months. During September 1984-August 1990 we registered 6 invasive tumours (18.18%). These results showed the dynamic evolution of Cis under long-term intravesical immune BCG stimulation.
我们使用膀胱内卡介苗（BCG）疗法分析了33例膀胱原位癌（Cis）的病情发展情况（2例原发性Cis，20例在浅表膀胱肿瘤手术治疗中的四象限活检时发现，5例在每3个月一次的评估性膀胱镜检查和膀胱染色镜检查时发现）。平均随访期为40个月。我们的免疫治疗方案持续了3年（最初8周每周一次，用100毫克罗马尼亚改良巴斯德BCG疫苗溶于50毫升生理盐水中灌注，随后10个月每月一次，然后2年每3个月一次，剂量相同）。我们阐述了这种“长疗程治疗”的重大意义：6个月后有12例持续性Cis，21个月后有2例持续性Cis。在1984年9月至1990年8月期间，我们记录到6例浸润性肿瘤（18.18%）。这些结果显示了在长期膀胱内BCG免疫刺激下Cis的动态发展情况。
