Konrádová V
Institute of Histology, 2nd Medical Faculty, Prague.
Funct Dev Morphol. 1991;1(3):47-50.
Quantitative evaluation of the injury to the tracheal epithelium was carried out under various experimental conditions. The damage of the epithelium was classified in three groups, according its severity. In several impaired epithelium all the goblet cells were stimulated to release their secretion. The mechanism of mucus discharge was maximally accelerated. Over 90% of the exhausted goblet cells degenerated. In average only 1 cilium/micron 2 was left in the ciliary border. Over 10% of the remaining cilia displayed signs of alteration. As morphological signs of impairment of the self-cleaning ability of the epithelium, large amounts of inspissated mucus and numerous bacteria were observed in the area of the damaged ciliary border. In moderately severe epithelial injury about 80% of the goblet cells were stimulated and half of them degenerated. The mean number of cilia in the ciliary border was 3/micron 2. The signs of impairment of the self-cleaning ability of the epithelium were less pronounced. In mild damage, about half of the goblet cells were stimulated and the degenerated ones formed less than 10% of all the mucous-secreting elements. The number of kinocilia per micron 2 fell on the average by one third. No signs of the self-cleaning ability impairment were recorded.
在各种实验条件下对气管上皮损伤进行了定量评估。根据上皮损伤的严重程度，将其分为三组。在一些受损的上皮中，所有杯状细胞均被刺激分泌其分泌物。黏液排出机制被最大程度地加速。超过90%的耗尽杯状细胞发生退化。在纤毛边界平均每平方微米仅残留1根纤毛。其余纤毛中超过10%表现出改变迹象。作为上皮自我清洁能力受损的形态学标志，在受损纤毛边界区域观察到大量浓缩黏液和众多细菌。在中度严重的上皮损伤中，约80%的杯状细胞受到刺激，其中一半发生退化。纤毛边界的纤毛平均数量为每平方微米3根。上皮自我清洁能力受损的迹象不太明显。在轻度损伤中，约一半的杯状细胞受到刺激，退化的杯状细胞占所有黏液分泌细胞的比例不到10%。每平方微米动纤毛数量平均下降三分之一。未记录到自我清洁能力受损的迹象。
