Izquierdo M L
Centro de Biología Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.
BioDrugs. 1998 Apr;9(4):337-49. doi: 10.2165/00063030-199809040-00006.
Tumour development is a disease of both somatic and genetic origin. It originates from a combination of oncogene and tumour suppressor alterations that force the cell into unprogrammed proliferation. It is reasonable to think that a genetic disease could be cured by gene therapy, and several strategies along this line are presently being employed. The use of retroviruses to carry 'suicide' genes has been the most successful approach to date for the treatment of neurological malignancies. The use of adenoviruses with deletions in the E1B region opens a new and elegant possibility for the destruction of tumours deficient in the p53 suppressor gene. Strategies based on the inhibition of angiogenesis are being developed, and those based on blockade of inducers of angiogenesis have given encouraging results in experimental animal models. However, gene therapy has not yet been able to permanently cure a human genetic disease, thereby creating a certain degree of caution among scientists and clinicians.
肿瘤发展是一种源于体细胞和遗传因素的疾病。它起源于致癌基因和肿瘤抑制因子的改变，这些改变迫使细胞进行无节制的增殖。认为基因疗法可以治愈遗传疾病是合理的，目前正在采用一些这方面的策略。使用逆转录病毒携带“自杀”基因是迄今为止治疗神经恶性肿瘤最成功的方法。使用在E1B区域有缺失的腺病毒为破坏缺乏p53抑制基因的肿瘤开辟了一种新的巧妙方法。基于抑制血管生成的策略正在开发中，基于阻断血管生成诱导剂的策略在实验动物模型中已取得了令人鼓舞的结果。然而，基因疗法尚未能够永久性地治愈人类遗传疾病，从而在科学家和临床医生中产生了一定程度的谨慎态度。
