May Abigail, Wang Thomas J
Massachusetts General Hospital, Department of Internal Medicine Harvard Medical School, Boston, MA 02114, USA.
Expert Rev Mol Diagn. 2007 Nov;7(6):793-804. doi: 10.1586/14737159.7.6.793.
Cardiovascular disease is a significant cause of morbidity and mortality, making cardiovascular prevention an important public health goal. The use of cardiac biomarkers represents a potential, noninvasive method to identify asymptomatic individuals who are most likely to develop cardiovascular disease. Several known biomarkers predict cardiovascular risk above and beyond conventional risk factors. Nonetheless, available evidence suggests that current biomarkers do not have sufficient sensitivity or specificity to justify widespread use for cardiovascular risk prediction. New developments in molecular biology and genetics may allow the identification of additional biomarkers, likely acting via different pathways, to achieve this goal.
心血管疾病是发病和死亡的重要原因，这使得心血管疾病预防成为一项重要的公共卫生目标。心脏生物标志物的应用是一种潜在的、非侵入性的方法，可用于识别最有可能患心血管疾病的无症状个体。几种已知的生物标志物能预测超出传统风险因素之外的心血管风险。尽管如此，现有证据表明，目前的生物标志物在敏感性或特异性方面不足以证明可广泛用于心血管风险预测。分子生物学和遗传学的新进展可能有助于识别更多的生物标志物，这些生物标志物可能通过不同途径发挥作用，从而实现这一目标。
