Rubin H, Alter A A, Walker M R, Stefanyshyn M, Scott L, Miotti A B
J Lab Clin Med. 1976 Jul;88(1):14-21.
Plasmas from a pregnant patient with von Willebrand's disease and from a patient with von Willebrand's disease who is taking Premarin had elevated levels of Factor VIII-related antigen and Factor VIII activity without any improvement in their platelet retention abnormality. When these were added to the blood from nonpregnant patients with von Willebrand's disease no significant improvement in platelet retention followed. This suggests that the "retention factor" is independent of the antigenic Factor VIII-like material.
患有血管性血友病的孕妇以及正在服用倍美力的血管性血友病患者的血浆中，VIII因子相关抗原和VIII因子活性水平升高，但其血小板滞留异常并未得到改善。当将这些血浆添加到非妊娠血管性血友病患者的血液中时，血小板滞留情况也未得到显著改善。这表明“滞留因子”独立于抗原性VIII因子样物质。
