在对甲基二溴戊二腈有或无过敏反应的皮炎患者中进行甲基二溴戊二腈的反复开放性应用试验。
Repeated open application tests with methyldibromoglutaronitrile in dermatitis patients with and without hypersensitivity to methyldibromoglutaronitrile.
作者信息
Isaksson Marléne, Gruvberger Birgitta, Bruze Magnus
机构信息
Department of Occupational and Environmental Dermatology, Lund University, Malmö University Hospital, Malmö, Sweden.
出版信息
Dermatitis. 2007 Dec;18(4):203-7. doi: 10.2310/6620.2007.06042.
BACKGROUND
Contact allergy to and allergic contact dermatitis from methyldibromoglutaronitrile (MDBGN) have been frequently reported since the 1990s.
OBJECTIVE
This study was initiated to help determine the optimal test preparation for MDBGN and to help determine the clinical relevance of such a contact allergy.
METHOD
In 38 patients with positive (32 patients) or doubtful (6 patients) patch-test reactions to at least one of four test preparations of MDBGN in petrolatum at 1.0%, 0.5%, 0.3%, and 0.1% (all weight per weight [w/w]), a repeated open application test (ROAT) with moisturizers with and without MDBGN at 0.03% w/w was conducted on patients' upper arms for a maximum of 4 weeks. Seven patients not hypersensitive to MDBGN served as controls and went through the same procedure.
RESULTS
Nineteen (59.4%) of the 32 MDBGN-allergic patients developed a positive ROAT result on the arm on which the moisturizer containing MDBGN was applied whereas no patients with doubtful or negative reactions to MDBGN reacted (p = .002). A statistically significant association was found between the patch-test reactivity and the outcome of the ROAT (p < .001).
CONCLUSION
Patch testing with MDBGN at 0.3% and 0.1% will miss clinically relevant patch-test reactions to MDBGN.
背景
自20世纪90年代以来，甲基二溴戊二腈（MDBGN）引起的接触性过敏及过敏性接触性皮炎屡有报道。
目的
开展本研究以确定MDBGN的最佳测试制剂，并确定此类接触性过敏的临床相关性。
方法
38例患者对凡士林基质中1.0%、0.5%、0.3%和0.1%（均为重量/重量[w/w]）的四种MDBGN测试制剂中至少一种的斑贴试验反应为阳性（32例患者）或可疑（6例患者），在患者上臂进行含和不含0.03% w/w MDBGN的保湿剂的重复开放应用试验（ROAT），最长持续4周。7例对MDBGN不过敏的患者作为对照，接受相同程序。
结果
32例MDBGN过敏患者中有19例（59.4%）在涂抹含MDBGN保湿剂的手臂上ROAT结果为阳性，而对MDBGN反应可疑或阴性的患者均无反应（p = 0.002）。斑贴试验反应性与ROAT结果之间存在统计学显著关联（p < 0.001）。
结论
用0.3%和0.1%的MDBGN进行斑贴试验会遗漏与临床相关的MDBGN斑贴试验反应。
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