Sobotka L, Zadak Z, Bures J, Pidrman V
Metabolic Care Unit, Faculty of Medicine, Charles University, Hradec Kralove, Czechoslovakia.
Nutrition. 1991 May-Jun;7(3):200-3; discussion 203-4.
The aim of this study was to observe the effect of rapid lipid and amino acid infusion on resting energy expenditure (REE) in patients on parenteral nutrition. Eight people were studied. After 8 h of saline administration, they received 20% lipid emulsion and 8% amino acid solution during the next 5 h (rate 3.8 mg.kg-1.min-1 fat and 1.9 mg.kg-1.min-1 amino acid). Before the onset of the infusion and 3 and 5 h after, gas exchange and REE were measured. The rapid lipid emulsion administration led to a significant rise in serum triglyceride level. A significant increase in VO2 (from 269.0 +/- 66.8 to 319 +/- 55.8 ml/min) and REE (from 1858 +/- 438 to 2155 +/- 385 kcal/24 h) was observed 5 h after the onset of substrate administration (P less than 0.01). Pulmonary ventilation and VCO2 production were not influenced by the infusion. The thermic effect of nutrients administered reached 3.5 and 6.5% 3 and 5 h after the start of infusion, respectively. We conclude that REE can be increased by the rapid administration of lipid-based parenteral nutrition.
本研究旨在观察快速输注脂肪和氨基酸对接受肠外营养患者静息能量消耗（REE）的影响。共研究了8人。在输注生理盐水8小时后，他们在接下来的5小时内接受了20%脂肪乳剂和8%氨基酸溶液（脂肪输注速率为3.8mg·kg-1·min-1，氨基酸输注速率为1.9mg·kg-1·min-1）。在输注开始前以及输注后3小时和5小时，测量气体交换和REE。快速输注脂肪乳剂导致血清甘油三酯水平显著升高。在底物输注开始5小时后，观察到VO2（从269.0±66.8增至319±55.8ml/min）和REE（从1858±438增至2155±385kcal/24h）显著增加（P<0.01）。肺通气和VCO2产生不受输注影响。在输注开始后3小时和5小时，所给予营养物质的热效应分别达到3.5%和6.5%。我们得出结论，快速给予基于脂肪的肠外营养可增加REE。
