免疫相关GTP酶（p47 GTP酶）对干扰素-γ介导的宿主抵抗细胞内病原体的控制。
Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases).
作者信息
Taylor Gregory A, Feng Carl G, Sher Alan
机构信息
Department of Medicine, Division of Geriatrics, Center for the Study of Aging and Human Development, Duke University Medical Center, NC 27705, USA.
出版信息
Microbes Infect. 2007 Nov-Dec;9(14-15):1644-51. doi: 10.1016/j.micinf.2007.09.004. Epub 2007 Sep 14.
IRG proteins (also known as p47 GTPases) are key mediators of interferon-gamma-induced resistance to pathogens. Absence of certain IRG proteins leads to profound susceptibility to protozoa and bacteria in mice. Underlying their roles in host resistance, IRG proteins regulate the processing of pathogen-containing vacuoles in host cells, and regulate hematopoiesis following infection.
免疫相关鸟苷三磷酸酶蛋白（也称为p47鸟苷三磷酸酶）是γ干扰素诱导的病原体抗性的关键介质。某些免疫相关鸟苷三磷酸酶蛋白的缺失会导致小鼠对原生动物和细菌极度易感。免疫相关鸟苷三磷酸酶蛋白在宿主抗性中发挥作用的基础是，它们调节宿主细胞中含病原体液泡的加工过程，并在感染后调节造血作用。
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