Taylor Gregory A, Feng Carl G, Sher Alan
Department of Medicine, Division of Geriatrics, and the Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27710, USA.
Nat Rev Immunol. 2004 Feb;4(2):100-9. doi: 10.1038/nri1270.
Activation of the innate immune system by interferon-gamma (IFN-gamma is crucial for host resistance to infection. IFN-gamma induces the expression of a wide range of mediators that undermine the ability of pathogens to survive in host cells, including a newly discovered family of 47-kDa GTPases. Elimination of different p47 GTPases in mice by gene targeting severely cripples IFN-gamma-regulated defence against Toxoplasma gondii, Listeria monocytogenes, Mycobacterium spp. and other pathogens. In this article, we review our understanding of the role of p47 GTPases in resistance to intracellular infection and discuss the present evidence concerning their mode of action.
γ干扰素（IFN-γ）激活先天性免疫系统对于宿主抵抗感染至关重要。IFN-γ诱导多种介质的表达，这些介质会破坏病原体在宿主细胞中存活的能力，包括新发现的一个47-kDa GTP酶家族。通过基因靶向消除小鼠体内不同的p47 GTP酶，会严重削弱IFN-γ调节的针对弓形虫、单核细胞增生李斯特菌、分枝杆菌属及其他病原体的防御能力。在本文中，我们回顾了对p47 GTP酶在抵抗细胞内感染中作用的理解，并讨论了有关其作用方式的现有证据。
