van Mil Saskia G M, Reijs Rianne P, van Hall Mariette H J A, Aldenkamp Albert P
Epilepsy Centre Kempenhaeghe, Department of Research and Development, Sterkselseweg 65, 5591 VE Heeze, The Netherlands.
Seizure. 2008 Jun;17(4):308-13. doi: 10.1016/j.seizure.2007.10.001. Epub 2007 Nov 19.
Up to one third of the children with epilepsy are classified as having cryptogenic localization epilepsy (CLRE). Unfortunately, not much is known on the prognosis of CLRE; it is assumed to be somewhere between the benign course of many idiopathic epilepsies and the more malignant course of most symptomatic epilepsies. The risk of cognitive decline over time seems to be increased for children with epilepsy, but no data are available specifically for CLRE. This study was a systematic cross-sectional open clinical and non-randomized investigation, which included 68 children with CLRE, 24 children with symptomatic localization related epilepsy (SLRE) and 21 children with idiopathic generalized epilepsy (IGE). One-way between-groups ANOVAs with Tukey post hoc testing were used to test differences in demographical variables and IQ between CLRE, SLRE and IGE and to test the influence of duration of epilepsy and other epilepsy factors on IQ. To test whether there were IQ differences between the three types of epilepsy regarding duration of epilepsy and other epilepsy factors, the Kruskal-Wallis test was used. In CLRE, intelligence is stable over time; IQ scores do neither improve nor deteriorate. Age at onset, seizure type, seizure frequency and the use of AED appeared to have no influence on intelligence in CLRE. Furthermore, over time, there appeared to be no differentiation regarding IQ between CLRE, SLRE and IGE.
高达三分之一的癫痫儿童被归类为隐源性局灶性癫痫（CLRE）。不幸的是，关于CLRE的预后了解不多；据推测，其预后介于许多特发性癫痫的良性病程和大多数症状性癫痫的更恶性病程之间。随着时间的推移，癫痫儿童认知能力下降的风险似乎有所增加，但尚无专门针对CLRE的数据。本研究是一项系统性横断面开放性临床非随机调查，纳入了68例CLRE儿童、24例症状性局灶性相关性癫痫（SLRE）儿童和21例特发性全身性癫痫（IGE）儿童。采用组间单因素方差分析及Tukey事后检验，以检验CLRE、SLRE和IGE在人口统计学变量和智商方面的差异，并检验癫痫病程和其他癫痫因素对智商的影响。为检验三种类型癫痫在癫痫病程和其他癫痫因素方面的智商差异，采用了Kruskal-Wallis检验。在CLRE中，智力随时间保持稳定；智商分数既没有提高也没有下降。发病年龄、发作类型、发作频率和抗癫痫药物（AED）的使用似乎对CLRE的智力没有影响。此外，随着时间的推移，CLRE、SLRE和IGE在智商方面似乎没有差异。
