新诊断的特发性儿童癫痫患儿的神经心理状态

Neuropsychological status of children with newly diagnosed idiopathic childhood epilepsy.

作者信息

Jeong Min Hee, Yum Mi-Sun, Ko Tae-Sung, You Su Jeong, Lee Eun Hye, Yoo Hanik K

机构信息

Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap-Dong, Sonpa-Gu, Seoul 138-736, Republic of Korea.

出版信息

Brain Dev. 2011 Sep;33(8):666-71. doi: 10.1016/j.braindev.2010.11.003. Epub 2011 Jan 20.

DOI:10.1016/j.braindev.2010.11.003

PMID:21255950

Abstract

We characterized the neuropsychological status of children with newly diagnosed idiopathic childhood epilepsy and measured differences in IQ between children with different types of epilepsy. The Korean Education Development Institute-Wechsler Intelligence Scale for Children (KEDI-WISC) was administered to 72 patients (35 males and 37 females), of mean age 8.7±2.6 years, with newly diagnosed idiopathic childhood epilepsy. Of these patients, 22 (30.6%) had generalized epilepsy, 48 (66.7%) localization-related epilepsy, and 2 (2.8%) mixed epilepsy. Children with generalized epilepsy and benign childhood epilepsy with centro-temporal spikes (BCECTS) were of similar verbal IQ and full-scale IQ, although performance IQ was significantly lower in patients with generalized epilepsy. Among children with BCECTS, those with unilateral spikes had higher full-scale and performance IQ scores than those with bilateral spikes. Follow-up studies on large numbers of patients are needed to determine the effects of epilepsy per se, and antiepileptic drugs, on intelligence.

摘要

我们对新诊断的特发性儿童癫痫患儿的神经心理状态进行了表征，并测量了不同类型癫痫患儿之间的智商差异。对72例新诊断为特发性儿童癫痫的患者（35名男性和37名女性）进行了韩国教育发展研究院儿童韦氏智力量表（KEDI-WISC）测试，这些患者的平均年龄为8.7±2.6岁。在这些患者中，22例（30.6%）患有全身性癫痫，48例（66.7%）患有局灶性相关性癫痫，2例（2.8%）患有混合型癫痫。全身性癫痫患儿和伴有中央颞区棘波的儿童良性癫痫（BCECTS）患儿的言语智商和全量表智商相似，尽管全身性癫痫患者的操作智商显著较低。在BCECTS患儿中，单侧棘波患儿的全量表和操作智商得分高于双侧棘波患儿。需要对大量患者进行随访研究，以确定癫痫本身以及抗癫痫药物对智力的影响。