关于滚压法制粒片剂可压性降低的机制
On the mechanism of reduced tabletability of granules prepared by roller compaction.
作者信息
Sun Changquan Calvin
出版信息
Int J Pharm. 2008 Jan 22;347(1-2):171-2; author reply 173-4. doi: 10.1016/j.ijpharm.2007.10.002. Epub 2007 Oct 10.
Abstract
In a recent paper published in this journal, authors were perplexed by their results seemingly conflicting with our earlier findings [Sun, C.C., Himmelspach, M.W., 2006. Reduced tabletability of roller compacted granules as a result of granule size enlargement. J. Pharm. Sci. 95, 200-206]. After carefully reviewing the two studies, we conclude that results in the two studies are actually consistent with each other.
摘要
在最近发表于本期刊的一篇论文中，作者们对其结果似乎与我们早期的发现相冲突感到困惑[孙，C.C.，希默尔斯巴赫，M.W.，2006年。由于颗粒尺寸增大导致滚压颗粒的可压性降低。《药学杂志》95，200 - 206]。在仔细审查这两项研究后，我们得出结论，这两项研究的结果实际上是相互一致的。
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