Rolland Amandine, Boquet Isabelle, Norreel Jean-Chrétien, Moret Vincent, Laras Younes, Kraus Jean-Louis
Laboratoire de Chimie Biomoléculaire, UMR-CNRS 6216, IBDML, Université de la Méditerranée, Parc Scientifique de Luminy, case 901, 13288 Marseille cedex 9, France.
Bioorg Med Chem Lett. 2008 Jan 1;18(1):169-74. doi: 10.1016/j.bmcl.2007.10.112. Epub 2007 Nov 4.
Using SVZ (subventricular zone) tissue explants from one-day-old mice, we investigated the activity of new amino aromatic disulfide analogues and polyazamacrocycles on the migration of SVZ cells (neuroblasts). We found that among the tested analogues, non-peptidic disulfide derivative 8 significantly decreases the migration of neuroblasts from SVZ cells, and antagonized the stimulating activity of disulfide cyclic peptide 1. Discovery of compounds 1 and 8 constitutes new chemical tools which could be used to understand the mechanism of neuroblast migration during neurogenesis and eventually to identify specific genes involved in the neurogenesis.
利用新生一天小鼠的脑室下区（SVZ）组织外植体，我们研究了新型氨基芳族二硫化物类似物和多氮大环化合物对SVZ细胞（神经母细胞）迁移的活性。我们发现，在所测试的类似物中，非肽二硫化物衍生物8显著降低了神经母细胞从SVZ细胞的迁移，并拮抗了二硫化物环肽1的刺激活性。化合物1和8的发现构成了新的化学工具，可用于理解神经发生过程中神经母细胞迁移的机制，并最终鉴定参与神经发生的特定基因。
