二甘醇：广泛使用的溶剂存在严重的中毒风险。
Diethylene glycol: widely used solvent presents serious poisoning potential.
作者信息
Marraffa Jeanna M, Holland Michael G, Stork Christine M, Hoy Christopher D, Hodgman Michael J
机构信息
Department of Emergency Medicine, State University of New York (SUNY) Upstate Medical University, Central New York Poison Center, Syracuse, New York 13210, USA.
出版信息
J Emerg Med. 2008 Nov;35(4):401-6. doi: 10.1016/j.jemermed.2007.06.025. Epub 2007 Nov 19.
OBJECTIVE
To describe the serious toxicity of a readily available solvent, diethylene glycol (DEG). We describe a case of intentional ingestion of a wallpaper stripper containing DEG resulting in severe multi-system organ failure.
CASE REPORT
A 27-year-old male presented to the Emergency Department (ED) one day after ingesting wallpaper stripper containing DEG. He developed acidosis, renal cortical necrosis, hepatocellular injury, and severe neurologic sequelae, including cranial neuropathies and peripheral demyelinating sensori-motor polyneuropathy. His neurologic function improved over 5 months.
DISCUSSION
Our case demonstrates the severe toxicity of DEG. DEG is present in numerous formulations, often without proper protective packaging. DEG has been associated with severe epidemic poisonings in the past and with the availability of safer alternatives, DEG in consumer products should be eliminated.
CONCLUSION
DEG is found in numerous products. Delays in treatment can have devastating results, resulting in death or permanent disability. The pervasive use of this compound makes further human exposures likely.
目的
描述一种 readily available 溶剂——二甘醇（DEG）的严重毒性。我们描述了一例因故意摄入含 DEG 的墙纸剥离剂而导致严重多系统器官衰竭的病例。
病例报告
一名 27 岁男性在摄入含 DEG 的墙纸剥离剂一天后就诊于急诊科。他出现了酸中毒、肾皮质坏死、肝细胞损伤以及严重的神经后遗症，包括颅神经病变和周围脱髓鞘感觉运动性多发性神经病。他的神经功能在 5 个月内有所改善。
讨论
我们的病例证明了 DEG 的严重毒性。DEG 存在于众多配方中，通常没有适当的防护包装。过去，DEG 曾与严重的流行中毒事件相关，且鉴于有更安全的替代品可供使用，消费品中的 DEG 应予以消除。
结论
DEG 存在于众多产品中。治疗延迟可能会产生毁灭性后果，导致死亡或永久性残疾。这种化合物的广泛使用使得人类进一步接触成为可能。
Zotero 插件