Piehler Armin P, Haug Kari Bente Foss, Wenzel Jürgen J, Kierulf Peter B, Kaminski Wolfgang E
Klinisk kjemisk avdeling, Ullevål universitetssykehus, 0407 Oslo.
Tidsskr Nor Laegeforen. 2007 Nov 15;127(22):2930-3.
The transport of lipids, which is orchestrated by a multitude of molecular factors, is a key feature of the physiology of living cells. A new group of transporter protein, the A-subclass of ATP-binding cassette (ABC) transporters, was recently discovered. ABCA-transporters play pivotal roles in cellular lipid transport and their discovery has brought important new insights into the molecular basis of this process. This review article presents the biology of ABCA-transport proteins and their implication for clinical medicine.
Literature retrieved from Pubmed, including own research results, formed the basis for the article.
Mutations in ABCA-transporter genes have been shown to result in hereditary diseases involving major physiologicical processes in the cardiovascular, respiratory, visual and integumentary systems. Accumulated evidence suggests that ABCA-transporters play critical roles in the pathogenesis of complex multifactorial disorders with a high incidence; such as atherosclerosis, age-related macula degeneration and Alzheimer's disease.
脂质的转运由多种分子因子协调进行，是活细胞生理学的一个关键特征。最近发现了一组新的转运蛋白，即ATP结合盒（ABC）转运蛋白的A亚类。ABCA转运蛋白在细胞脂质转运中起关键作用，它们的发现为这一过程的分子基础带来了重要的新见解。这篇综述文章介绍了ABCA转运蛋白的生物学特性及其对临床医学的意义。
从PubMed检索到的文献，包括自身的研究结果，构成了本文的基础。
已表明ABCA转运蛋白基因突变会导致涉及心血管、呼吸、视觉和皮肤系统主要生理过程的遗传性疾病。越来越多的证据表明，ABCA转运蛋白在发病率较高的复杂多因素疾病的发病机制中起关键作用，如动脉粥样硬化、年龄相关性黄斑变性和阿尔茨海默病。
