Prasad Rajendra, Khandelwal Nitesh Kumar, Banerjee Atanu
Institute of Integrative Sciences and Health and Institute of Biotechnology, Amity University Haryana, Amity Education Valley, Gurgaon, India; Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Fungal Genet Biol. 2016 Aug;93:25-34. doi: 10.1016/j.fgb.2016.05.008. Epub 2016 Jun 1.
Throughout its evolution, the ATP-binding cassette (ABC) transporter superfamily has experienced a rapid expansion in its substrate repertoire and functions. Of the diverse functions that these pumps offer, their drug transport properties have attracted considerable attention primarily owing to their clinical significance. Despite this fact, emerging evidence suggests that physiological substrates of transporters also affect the overall functioning of an organism. Lipids, as substrates of ABC transporters, constitute one feature found in all representative groups of the living kingdom. Due to the importance of lipid species in the cellular physiology of an organism, their proper distribution within cells is crucial. This fact is well exemplified by the vast number of medical conditions that have been caused as a result of perturbations in ABC transporter-mediated lipid transport in higher organisms. In yeasts, apart from providing transport functions, ABC transporters also coordinate regulatory networks with lipids. This review focuses on yeast ABC transporters involved in the transport of lipids and briefly discusses the integration of their regulatory network with that of the lipid species.
在其进化过程中，ATP结合盒（ABC）转运蛋白超家族的底物种类和功能经历了快速扩展。在这些泵所提供的多种功能中，它们的药物转运特性主要因其临床意义而备受关注。尽管如此，新出现的证据表明，转运蛋白的生理底物也会影响生物体的整体功能。脂质作为ABC转运蛋白的底物，是生物界所有代表性类群中都存在的一个特征。由于脂质种类在生物体细胞生理学中的重要性，它们在细胞内的正确分布至关重要。高等生物中ABC转运蛋白介导的脂质转运受到干扰而导致大量医学病症，这一事实很好地例证了这一点。在酵母中，ABC转运蛋白除了提供转运功能外，还与脂质协调调控网络。本综述重点关注参与脂质转运的酵母ABC转运蛋白，并简要讨论其调控网络与脂质种类调控网络的整合。
