Muturi Ephantus J, Jacob Benjamin G, Kim Chang-Hyun, Mbogo Charles M, Novak Robert J
Department of Medicine, William C. Gorgas Center for Geographic Medicine, University of Alabama at Birmingham, 206C Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL, 35294, USA.
Parasitol Res. 2008 Jan;102(2):175-81. doi: 10.1007/s00436-007-0779-1. Epub 2007 Nov 20.
Africa accounts for about 33 and 90% of the world's burden of lymphatic filariasis (LF) and malaria, respectively. Despite tremendous progress in the approach to their diagnosis, epidemiology, and treatment, and global campaigns for their control and/or elimination, their global burden and economic costs have continued to rise. In most rural areas of the tropics, both diseases co-occur in the same human population and share common mosquito vectors. It is therefore conceived that control of the two diseases can be integrated using tools that have been proven effective recently or in the past. Before implementation of control programs in areas co-endemic for both diseases, it is deemed necessary to understand how the two diseases interact in the vector and human hosts. Here, we summarize available knowledge on coinfections of malaria and LF and provide an insight on how they can be managed.
非洲分别占全球淋巴丝虫病（LF）和疟疾负担的约33%和90%。尽管在它们的诊断、流行病学和治疗方法上取得了巨大进展，以及开展了全球防治和/或消除运动，但它们的全球负担和经济成本仍在持续上升。在热带地区的大多数农村地区，这两种疾病在同一人群中同时存在，并共享常见的蚊媒。因此，可以设想利用最近或过去已被证明有效的工具来整合这两种疾病的防治。在两种疾病共同流行的地区实施控制项目之前，有必要了解这两种疾病在媒介和人类宿主中是如何相互作用的。在这里，我们总结了关于疟疾和LF合并感染的现有知识，并对如何管理它们提供了见解。
