Nagpal J, Bhartia A
Sitaram Bhartia Institute of Science and Research, Qutab Institutional Area, New Delhi, India.
Diabet Med. 2008 Jan;25(1):27-36. doi: 10.1111/j.1464-5491.2007.02307.x. Epub 2007 Nov 19.
To determine the cardiovascular risk profile of known diabetic patients from the middle- and high-income group populace of Delhi.
A cross-sectional survey was conducted using a probability proportionate to size (systematic) two-stage cluster design. Thirty areas were selected for a house-to-house survey to recruit a minimum of 25 subjects (known diabetes > or = 1 year; 35-65 years of age) per area. Data were collected by interview, blood sampling and from medical records. Scores from the Framingham, Joint British Society, United Kingdom Prospective Diabetes Study, Systematic Coronary Risk Evaluation, and Diabetes Epidemiology: Collaborative Analysis Of Diagnostic Criteria in Europe studies were used to calculate summary estimates of risk for coronary heart disease (CHD) and stroke.
Eight hundred and nineteen subjects (25-30 per cluster) were enrolled. The mean age of the subjects was 53.6 years, the mean duration since diagnosis was 8.1 years, the mean body mass index was 28.1 kg/m(2), with 50.7% women; 74.3% had hypertension, 75.1% dyslipidaemia and 41.8% had poor glycaemic control (HbA(1c) > 8.0%); 8.4% had already had a myocardial infarction, whereas 2.3% had suffered a stroke. Only 17.6% were taking aspirin, 3.4% were on lipid-lowering drugs and 11.6% were taking antihypertensive agents. The risk engines estimated a 10-year CHD risk of 12.6-13.9% and a stroke risk of 5.1-5.7%.
The study documents that the cardiovascular profile of known diabetes patients from the middle and higher income groups of Delhi is poor, strengthening the case for targeting interventions at patients, providers and other stakeholders for improvement.
确定德里中高收入群体中已知糖尿病患者的心血管风险状况。
采用按规模比例概率抽样(系统抽样)的两阶段整群设计进行横断面调查。选取30个地区进行挨家挨户调查,每个地区至少招募25名受试者(已知糖尿病≥1年;年龄35 - 65岁)。通过访谈、采血和查阅医疗记录收集数据。使用弗雷明汉、英国联合协会、英国前瞻性糖尿病研究、系统性冠心病风险评估以及欧洲糖尿病流行病学:诊断标准协作分析研究的评分来计算冠心病(CHD)和中风风险的汇总估计值。
共纳入819名受试者(每个整群25 - 30人)。受试者的平均年龄为53.6岁,诊断后的平均病程为8.1年,平均体重指数为28.1kg/m²,女性占50.7%;74.3%患有高血压,75.1%患有血脂异常,41.8%血糖控制不佳(糖化血红蛋白>8.0%);8.4%已发生心肌梗死,而2.3%曾患中风。仅17.6%的人服用阿司匹林,3.4%的人服用降脂药物,11.6%的人服用抗高血压药物。风险评估工具估计10年冠心病风险为12.6% - 13.9%,中风风险为5.1% - 5.7%。
该研究表明,德里中高收入群体中已知糖尿病患者的心血管状况较差,这进一步证明了针对患者、医疗服务提供者和其他利益相关者进行干预以改善状况的必要性。