Wang Hongbei, Wieczorek Rosemary L, Zenilman Michael E, Desoto-Lapaix Fidelina, Ghosh Bimal C, Bowne Wilbur B
Department of Pathology, The State University of New York, Health Science Center of Brooklyn, NY, USA.
World J Surg Oncol. 2007 Nov 20;5:133. doi: 10.1186/1477-7819-5-133.
Castleman's disease of the pancreas is a very rare condition that may resemble more common disease entities as well as pancreatic cancer.
Here we report the case of a 58-year-old African American male with an incidentally discovered lesion in the head of the pancreas. The specimen from his pancreaticoduodectomy contained a protuberant, encapsulated mass, exhibiting microscopic features most consistent with localized/unicentric Castleman's disease. These included florid follicular hyperplasia with mantle/marginal zone hyperplasia along with focal progressive transformation of germinal centers admixed with involuted germinal centers.
To date, eight cases of Castleman's disease associated with the pancreas have been described in the world literature. We report the first case of unicentric disease situated within the head of the pancreas. In addition, we discuss the diagnostic dilemma Castleman's disease may present to the pancreatic surgeon and review current data on pathogenesis, treatment, and outcome.
胰腺Castleman病是一种非常罕见的疾病，可能类似于更常见的疾病实体以及胰腺癌。
在此，我们报告一例58岁非裔美国男性，其胰腺头部偶然发现病变。他的胰十二指肠切除标本包含一个突出的、有包膜的肿块，显微镜下特征最符合局限性/单中心Castleman病。这些特征包括明显的滤泡增生伴套区/边缘区增生，以及生发中心的局灶性进行性转化并伴有退化的生发中心。
迄今为止，世界文献中已描述了8例与胰腺相关的Castleman病。我们报告了首例位于胰腺头部的单中心疾病病例。此外，我们讨论了Castleman病可能给胰腺外科医生带来的诊断困境，并回顾了目前关于发病机制、治疗和预后的数据。
