Falanga V, Kruskal J B, Franks J J
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL 33101.
J Am Acad Dermatol. 1991 Nov;25(5 Pt 1):771-5. doi: 10.1016/s0190-9622(08)80967-x.
Abnormalities in fibrin deposition are implicated in the pathogenesis of vascular occlusion in systemic sclerosis. We have used a technique that involves electrophoresis and densitometric analysis of captured fibrin- and fibrinogen-related antigens to measure the concentration of the individual fibrin and fibrinogen degradation products in 13 patients with systemic sclerosis and in 15 healthy control subjects. As a group, patients with systemic sclerosis had markedly elevated levels of total fibrin-related antigen (p = 0.0007) and D-dimer (p = 0.0004), the terminal degradation product of cross-linked fibrin. The levels of fibrin monomer, an intermediate product in the conversion of fibrinogen to cross-linked fibrin, and of D-monomer, a terminal breakdown fragment of fibrinogen and fibrin monomer, were also elevated (p less than 0.005). We conclude that patients with systemic sclerosis have evidence of enhanced fibrin formation and degradation.
纤维蛋白沉积异常与系统性硬化症血管闭塞的发病机制有关。我们采用了一种技术，该技术涉及对捕获的纤维蛋白和纤维蛋白原相关抗原进行电泳和光密度分析，以测量13例系统性硬化症患者和15名健康对照者中单个纤维蛋白和纤维蛋白原降解产物的浓度。作为一个群体，系统性硬化症患者的总纤维蛋白相关抗原水平（p = 0.0007）和交联纤维蛋白的终末降解产物D - 二聚体水平（p = 0.0004）显著升高。纤维蛋白单体（纤维蛋白原转化为交联纤维蛋白过程中的中间产物）和D - 单体（纤维蛋白原和纤维蛋白单体的终末分解片段）的水平也升高（p < 0.005）。我们得出结论，系统性硬化症患者有纤维蛋白形成和降解增强的证据。
