Igwebuike Ada, Irving Brian A, Bigelow Maureen L, Short Kevin R, McConnell Joseph P, Nair K Sreekumaran
Division of Endocrinology, Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Joseph 5-194, Rochester, Minnesota 55905, USA.
J Clin Endocrinol Metab. 2008 Feb;93(2):534-8. doi: 10.1210/jc.2007-1027. Epub 2007 Nov 20.
Recent studies disputed the widely promoted anti-aging effect of dehydroepiandrosterone (DHEA) supplementation; however, conflicting data exist on whether physiological DHEA supplementation enhances exercise training effects on body composition, physical performance, and cardiometabolic risk in healthy postmenopausal women.
The aim of this study was to determine whether 12 wk of DHEA supplementation (50 mg/d) in postmenopausal women enhances exercise-related changes in body composition, physical performance, and cardiometabolic risk.
This study was a 12-wk randomized double-blind, placebo-controlled trial and took place at the Mayo Clinic General Clinical Research Center (Rochester, MN).
Thirty-one sedentary, postmenopausal, Caucasian women (mean +/- sem age 64.6 +/- 1.0 yr) completed the study.
Participants were randomized to one of two 12-wk interventions: 1) exercise training plus 50 mg/d of DHEA (n = 17), or 2) exercise training plus placebo (n = 14). The exercise intervention consisted of both endurance (4 d/wk) and resistance (3 d/wk) exercise components.
The main outcomes were measures of body composition, physical performance, and measures of cardiometabolic risk.
DHEA treatment with exercise resulted in increases in circulating sulfated DHEA (650%), total testosterone (100%), estradiol (165%), estrone (85%), and IGF-I (30%) (all P < or = 0.05, for all within and between treatment comparisons). Although exercise training alone significantly improved physical performance, body composition, and insulin sensitivity, administration of DHEA provided no additional benefits.
Twelve weeks of combined endurance and resistance training significantly improved body composition, physical performance, insulin sensitivity, and low-density lipoprotein cholesterol particle number and size, whereas DHEA had no additional benefits.
近期研究对广泛宣传的补充脱氢表雄酮（DHEA）的抗衰老作用提出质疑；然而，关于补充生理剂量的DHEA是否能增强运动训练对健康绝经后女性身体成分、身体机能和心脏代谢风险的影响，存在相互矛盾的数据。
本研究旨在确定绝经后女性补充12周DHEA（50毫克/天）是否能增强与运动相关的身体成分、身体机能和心脏代谢风险的变化。
本研究是一项为期12周的随机双盲、安慰剂对照试验，在梅奥诊所综合临床研究中心（明尼苏达州罗切斯特）进行。
31名久坐不动的绝经后白人女性（平均年龄±标准差为64.6±1.0岁）完成了该研究。
参与者被随机分为两个为期12周的干预组之一：1）运动训练加50毫克/天的DHEA（n = 17），或2）运动训练加安慰剂（n = 14）。运动干预包括耐力训练（每周4天）和阻力训练（每周3天）。
主要观察指标为身体成分、身体机能指标以及心脏代谢风险指标。
运动加DHEA治疗使循环硫酸化DHEA增加（650%）、总睾酮增加（100%）、雌二醇增加（165%）、雌酮增加（85%）和胰岛素样生长因子-I增加（30%）（所有组内和组间治疗比较的P均≤0.05）。尽管单独的运动训练显著改善了身体机能、身体成分和胰岛素敏感性，但补充DHEA并未带来额外益处。
为期12周的耐力和阻力联合训练显著改善了身体成分、身体机能、胰岛素敏感性以及低密度脂蛋白胆固醇颗粒数量和大小，而DHEA并无额外益处。
