He ShuYun, Lu Kunna, Zhang Lianying, Cao Hanwen, Tang Xinyuan, Zhang Xinhuan
Department of Geriatrics, The Second Affiliated Hospital of Shandong First Medical University, Tai'an City, 271000, Shandong Province, China.
Department of Endocrinology, The Second Affiliated Hospital of Shandong First Medical University, Tai'an City, 271000, Shandong Province, China.
Diabetol Metab Syndr. 2025 Jul 4;17(1):258. doi: 10.1186/s13098-025-01770-0.
The effects of dehydroepiandrosterone (DHEA) supplementation on testosterone and estradiol concentrations in postmenopausal women have produced conflicting results. This meta-analysis of randomized controlled trials aimed to evaluate the impact of DHEA supplementation on serum testosterone and estradiol levels and to provide evidence regarding the optimal dosage and duration of supplementation.
A comprehensive literature search was conducted across PubMed/Medline, Embase, Web of Science, and Scopus to identify relevant studies published before June 11, 2024. Data were analyzed using a random-effects model and presented as weighted mean differences (WMDs) with 95% confidence intervals (CIs).
The analysis included 21 studies, comprising 17 trial arms assessing estradiol and 20 assessing testosterone. DHEA supplementation significantly increased estradiol (WMD: 7.86 pg/mL; 95% CI 6.33-9.40; P ≤ 0.001) and testosterone levels (WMD: 24.31 ng/dL; 95% CI 15.22-33.40; P ≤ 0.001). Subgroup analyses showed greater increases in estradiol levels among studies using DHEA dosages ≥ 50 mg/day (WMD: 8.65 pg/mL) and those with participants aged ≥ 60 years (WMD: 8.92 pg/mL), although the differences were modest and 95% CIs overlapped. For testosterone, higher levels were observed with DHEA dosages ≥ 50 mg/day (WMD: 29.65 ng/dL).
DHEA supplementation at doses ≥ 50 mg/day significantly increases testosterone levels in postmenopausal women. Moreover, in women aged ≥ 60 years, supplementation at the same dosage significantly elevates estradiol levels.
补充脱氢表雄酮（DHEA）对绝经后女性睾酮和雌二醇浓度的影响产生了相互矛盾的结果。这项随机对照试验的荟萃分析旨在评估补充DHEA对血清睾酮和雌二醇水平的影响，并提供有关最佳补充剂量和持续时间的证据。
在PubMed/Medline、Embase、Web of Science和Scopus上进行了全面的文献检索，以识别2024年6月11日前发表的相关研究。使用随机效应模型分析数据，并以加权平均差（WMD）和95%置信区间（CI）表示。
该分析纳入了21项研究，其中17个试验组评估雌二醇，20个评估睾酮。补充DHEA显著提高了雌二醇（WMD：7.86 pg/mL；95%CI 6.33 - 9.40；P≤0.001）和睾酮水平（WMD：24.31 ng/dL；95%CI 15.22 - 33.40；P≤0.001）。亚组分析显示，在使用DHEA剂量≥50 mg/天的研究中（WMD：8.65 pg/mL）以及参与者年龄≥60岁的研究中（WMD：8.92 pg/mL），雌二醇水平升高幅度更大，尽管差异不大且95%CI有重叠。对于睾酮，DHEA剂量≥50 mg/天的水平更高（WMD：29.65 ng/dL）。
每天补充≥50 mg剂量的DHEA可显著提高绝经后女性的睾酮水平。此外，在60岁及以上的女性中，相同剂量的补充可显著提高雌二醇水平。
