• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于自由基介导的硫挤出锡化反应合成新型4'-修饰的奈替米星A类似物。

Synthesis of novel 4'-modified neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation.

作者信息

Kumamoto Hiroki, Deguchi Kazuki, Takahashi Nonoko, Tanaka Hiromichi

机构信息

School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.

出版信息

Nucleic Acids Symp Ser (Oxf). 2004(48):1-2. doi: 10.1093/nass/48.1.1.

DOI:10.1093/nass/48.1.1
PMID:17150448
Abstract

A new approach was developed for the synthesis of 4'-modified neplanocin A, as potential inhibitors against S-adenosyl-L-homocysteine hydrolase. Vinylstannane derivative 5, a key intermediate in the present approach, was prepared by radical-mediated sulfur-extrusive stannylation.

摘要

开发了一种合成4'-修饰的奈普拉诺辛A的新方法，作为潜在的S-腺苷-L-高半胱氨酸水解酶抑制剂。本方法中的关键中间体乙烯基锡烷衍生物5通过自由基介导的硫挤出锡化反应制备。

相似文献

1
Synthesis of novel 4'-modified neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation.基于自由基介导的硫挤出锡化反应合成新型4'-修饰的奈替米星A类似物。
Nucleic Acids Symp Ser (Oxf). 2004(48):1-2. doi: 10.1093/nass/48.1.1.
2
Synthesis of 5'-branched neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation.基于自由基介导的硫挤出锡化反应合成5'-支链奈替米星A类似物
Nucleic Acids Symp Ser (Oxf). 2007(51):145-6. doi: 10.1093/nass/nrm073.
3
Synthesis of novel 4'-modified neplanocin A analogues and their inhibitory activity against S-adenosyl-L-l-homocysteine hydrolase.新型4'-修饰的奈替米星A类似物的合成及其对S-腺苷-L-高半胱氨酸水解酶的抑制活性。
Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):733-6. doi: 10.1080/15257770701493617.
4
Sulfur extrusion with tin radical: synthesis of 4',5'-didehydro-5'-deoxy-5'-(tributylstannyl)adenosine, an intermediate for potential inhibitors against S-adenosyl homocysteine hydrolase.锡自由基促进的硫原子消除反应：4',5'-二脱氢-5'-脱氧-5'-(三丁基锡基)腺苷的合成，一种潜在的S-腺苷同型半胱氨酸水解酶抑制剂的中间体。
J Org Chem. 2004 Jan 9;69(1):72-8. doi: 10.1021/jo030256y.
5
New neplanocin analogues. 7. Synthesis and antiviral activity of 2-halo derivatives of neplanocin A.新型奈普诺辛类似物。7. 奈普诺辛A的2-卤代衍生物的合成及抗病毒活性。
J Med Chem. 1996 Sep 13;39(19):3847-52. doi: 10.1021/jm960145+.
6
Stereo-defined synthesis of 5'-(Z)-substituted 4',5'-unsaturated adenosines and evaluation of their inhibitory activity against S-adenosyl homocysteine hydrolase.5'-(Z)-取代的4',5'-不饱和腺苷的立体定向合成及其对S-腺苷同型半胱氨酸水解酶抑制活性的评价。
Nucleic Acids Res Suppl. 2003(3):13-4. doi: 10.1093/nass/3.1.13.
7
Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-adenosylhomocysteine hydrolase.卤代新制癌菌素A作为基于新机制的S-腺苷同型半胱氨酸水解酶抑制剂的合成及生物学评价
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):589-92. doi: 10.1081/NCN-120021961.
8
Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase.2-修饰阿瑞霉素及其类似物的合成作为恶性疟原虫S-腺苷-L-高半胱氨酸水解酶的有效抑制剂
Bioorg Med Chem. 2008 Apr 1;16(7):3809-15. doi: 10.1016/j.bmc.2008.01.046. Epub 2008 Jan 30.
9
Synthesis of 5'-substituted fluoro-neplanocin A analogues: importance of a hydrogen bonding donor at 5'-position for the inhibitory activity of S-adenosylhomocysteine hydrolase.5'-取代氟代新制癌菌素A类似物的合成：5'-位氢键供体对S-腺苷同型半胱氨酸水解酶抑制活性的重要性
Bioorg Med Chem Lett. 2004 Nov 15;14(22):5641-4. doi: 10.1016/j.bmcl.2004.08.047.
10
4'-modified analogues of aristeromycin and neplanocin A: synthesis and inhibitory activity toward S-adenosyl-L-homocysteine hydrolase.阿瑞吡坦和奈拉滨的4'-修饰类似物：合成及其对S-腺苷-L-高半胱氨酸水解酶的抑制活性
J Med Chem. 1992 May 15;35(10):1782-91. doi: 10.1021/jm00088a013.