人类端粒杂交G-四链体结构的折叠途径
Folding pathways of human telomeric hybrid G-quadruplex structure.
作者信息
Mashimo Tomoko, Sugiyama Hiroshi
机构信息
Department of Chemistry, Graduate Schoool of Science, Kyoto University, Kitashirakawa Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan.
出版信息
Nucleic Acids Symp Ser (Oxf). 2007(51):239-40. doi: 10.1093/nass/nrm120.
The human telomeric DNA sequence d[AGGG(TTAGGG)(3)] forms the G-quadruplex structure. The G-quadruplex structure has become an attractive target for the anticancer drugs, because it effectively inhibits telomerase activity. Recently, the human telomere G-quadruplex in K(+) solution has been determined as a hybrid of mixed parallel and antiparallel structures. In this study, we investigated the folding pathway of human telomeric hybrid G-quadruplex structure.
人类端粒DNA序列d[AGGG(TTAGGG)(3)]形成G-四链体结构。G-四链体结构已成为抗癌药物的一个有吸引力的靶点，因为它能有效抑制端粒酶活性。最近，在K(+)溶液中的人类端粒G-四链体已被确定为混合平行和反平行结构的杂合体。在本研究中，我们研究了人类端粒杂合G-四链体结构的折叠途径。
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