2H磷酸二酯酶家族蛋白的结构比较分析

Structural comparison analysis of 2H phosphodiesterase family proteins.

作者信息

Sakamoto Yasumitsu, Tanaka Nobutada, Ichimiya Tomomi, Kurihara Tadashi, Nakamura Kazuo T

机构信息

School of Pharmaceutical Sciences, Showa University, Tokyo 142-8555, Japan.

出版信息

Nucleic Acids Symp Ser (Oxf). 2007(51):447-8. doi: 10.1093/nass/nrm224.

DOI:10.1093/nass/nrm224

PMID:18029779

Abstract

2',3'-Cyclic-nucleotide 3'-phosphodiesterase (CNP) is found mainly in the central nervous system of vertebrates and catalyzes the hydrolysis of 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Recently, Several 2H phosphodiesterase super family protein structures have been determined by X-ray crystallography and NMR spectroscopy. Here we report the structure-function relationship studies of two hydrophobic residues in CNP family proteins.

摘要

2',3'-环核苷酸3'-磷酸二酯酶（CNP）主要存在于脊椎动物的中枢神经系统中，在体外催化2',3'-环核苷酸水解生成2'-核苷酸。最近，通过X射线晶体学和核磁共振光谱法确定了几种2H磷酸二酯酶超家族蛋白结构。在此，我们报告了CNP家族蛋白中两个疏水残基的结构-功能关系研究。