Mehta H J, Joseph L J, Desai K B, Mehta M N, Samuel A M, Almeida A F, Acharya V N
Department of Nephrology, K. E. M. Hospital, Bombay, Maharashtra.
J Postgrad Med. 1991 Apr;37(2):79-83.
The levels of serum total thyroxine (TT4), triiodothyronine (TT3), free T3, (FT3) free T4 (FT4) and thyrotropin (TSH) were measured in 127 clinically euthyroid patients with varying grades of chronic renal failure (CRF); and 97 healthy individuals. They were grouped as: Group I containing 93 patients on conservative management; Group II containing 34 patients on regular dialysis therapy; and Group III (normals). Group I patients showed significant decrease in TT3, TT4 and FT3 levels (p less than 0.001) as compared to Group III, whereas FT4 and TSH values in group I were not significantly altered. TT3, TT4 and FT3 levels reduced as the severity of renal damage increased. Variations in TT3, TT4, FT3, FT4 and TSH levels in Group II patients were similar to those in Group I, except for a decrease in TSH levels (p less than 0.05) as compared to normals. Several thyroid function tests are abnormal in CRF patients, however, finding of normal FT4 and TSH levels would indicate functional euthyroid status.
对127例不同程度慢性肾衰竭（CRF）的临床甲状腺功能正常患者及97名健康个体测定了血清总甲状腺素（TT4）、三碘甲状腺原氨酸（TT3）、游离T3（FT3）、游离T4（FT4）和促甲状腺激素（TSH）水平。他们被分为：第一组包含93例接受保守治疗的患者；第二组包含34例接受定期透析治疗的患者；第三组（正常对照组）。与第三组相比，第一组患者的TT3、TT4和FT3水平显著降低（p<0.001），而第一组的FT4和TSH值无显著变化。随着肾损害严重程度增加，TT3、TT4和FT3水平降低。第二组患者的TT3、TT4、FT3、FT4和TSH水平变化与第一组相似，但与正常对照组相比TSH水平降低（p<0.05）。CRF患者的多项甲状腺功能检查异常，然而，FT4和TSH水平正常表明甲状腺功能处于正常状态。
