Rohmer Damien, Sitek Arkadiusz, Gullberg Grant T
Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California, USA.
Invest Radiol. 2007 Nov;42(11):777-89. doi: 10.1097/RLI.0b013e3181238330.
The human heart is composed of a helical network of muscle fibers organized to form sheets that are separated by cleavage planes responsible for the orthotropic mechanical properties of cardiac muscle. The purpose of this study is the reconstruction and visualization of these structures in 3 dimensions.
Anisotropic least square filtering followed by fiber and sheet tracking techniques were applied to diffusion tensor magnetic resonance imaging data of the excised human heart. Fibers were reconstructed using the first eigenvectors of the diffusion tensors. The sheets were reconstructed using the second and third eigenvectors and visualized as surfaces.
The fibers are shown to lie in sheets that have transmural structure, which correspond to histologic studies published in the literature. Quantitative measurements show that the sheets as appose to the fibers are organized into laminar orientations without dominant populations.
A visualization algorithm was developed to demonstrate the complex 3-dimensional orientation of the fibers and sheets in human myocardium.
人类心脏由螺旋状的肌纤维网络组成，这些肌纤维组织形成薄片，薄片之间由负责心肌正交各向异性力学特性的解理面分隔。本研究的目的是对这些结构进行三维重建和可视化。
将各向异性最小二乘滤波以及纤维和薄片追踪技术应用于切除的人类心脏的扩散张量磁共振成像数据。使用扩散张量的第一特征向量重建纤维。使用第二和第三特征向量重建薄片并将其可视化为表面。
显示纤维位于具有透壁结构的薄片中，这与文献中发表的组织学研究结果一致。定量测量表明，与纤维相对的薄片被组织成层状取向，没有优势群体。
开发了一种可视化算法来展示人类心肌中纤维和薄片复杂的三维取向。
