Garampazzi Andrea, Rapa Anna, Mura Serena, Capelli Antonella, Valori Anna, Boldorini Renzo, Oderda Giuseppina
Department of Pediatrics, Università del Piemonte Orientale, Novara, Italy.
J Pediatr Gastroenterol Nutr. 2007 Nov;45(5):611-4. doi: 10.1097/MPG.0b013e31814c3d79.
The clinical presentation of celiac disease in children changed in the last decades of the 20th century. To ascertain whether changes are still in progress, we analyzed symptoms at presentation and age at diagnosis in 307 children receiving diagnoses of celiac disease for the past 20 years. The prevalence of typical forms of celiac disease decreased in the past decade, particularly in the past 5 years (from 76% in 1987-1990 to 44%, P < 0.0001). Age at diagnosis (5.9 y, P = 0.01) and silent forms (10.6%, P = 0.003) have significantly increased in the past 5 years. Histological examination showed decreased subtotal and increased partial villous atrophy prevalence (P = 0.02).
20世纪最后几十年里，儿童乳糜泻的临床表现发生了变化。为确定这些变化是否仍在继续，我们分析了过去20年中307例被诊断为乳糜泻的儿童的就诊症状和诊断年龄。在过去十年中，典型乳糜泻形式的患病率有所下降，尤其是在过去5年（从1987 - 1990年的76%降至44%，P < 0.0001）。在过去5年中，诊断年龄（5.9岁，P = 0.01）和无症状形式（10.6%，P = 0.003）显著增加。组织学检查显示，全层萎缩减少，部分绒毛萎缩患病率增加（P = 0.02）。
