Ferretti P, Whalley K
Developmental Biology Unit, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, United Kingdom.
Cell Mol Life Sci. 2008 Jan;65(1):45-53. doi: 10.1007/s00018-007-7430-2.
Although early after birth the central nervous system is more plastic than in the adult, it already displays limited regenerative capability. This becomes severely impaired at specific stages of embryonic development; however, the precise cellular and molecular basis of this loss is not fully understood. The chick embryo provides an ideal model for direct comparisons of regenerating and non-regenerating spinal cord within the same species because of its accessibility in ovo, the extensive knowledge of chick neural development and the molecular tools now available. Regenerative ability in the chick is lost at around E13, a relatively advanced stage of spinal cord development. This is most likely due to a complex series of events: there is evidence to suggest that developmentally regulated changes in the early response to injury, expression of inhibitory molecules and neurogenesis may contribute to loss of regenerative capacity in the chick spinal cord.
虽然出生后早期中枢神经系统比成年期更具可塑性，但它已经表现出有限的再生能力。在胚胎发育的特定阶段，这种能力会严重受损；然而，这种能力丧失的确切细胞和分子基础尚未完全明确。由于鸡胚在卵内易于操作、对鸡神经发育有广泛了解且现有分子工具，它为同一物种内再生和非再生脊髓的直接比较提供了理想模型。鸡的再生能力在大约E13（脊髓发育的一个相对晚期阶段）丧失。这很可能是由于一系列复杂事件：有证据表明，损伤早期反应中受发育调节的变化、抑制性分子的表达和神经发生可能导致鸡脊髓再生能力的丧失。
