Gallhofer B, Jaanson P, Mittoux A, Tanghøj P, Lis S, Krieger S
Cognitive Neuroscience Laboratory and Department of Psychiatry, Centre for Psychiatry, Justus-Liebig University, Giessen, Germany.
Pharmacopsychiatry. 2007 Nov;40(6):275-86. doi: 10.1055/s-2007-990291.
To compare the impact of sertindole and haloperidol on cognitive function in patients suffering from schizophrenia.
In a 12 week trial, of the 40 patients randomised to treatment, 34 (17 sertindole and 17 haloperidol) were included in the analysis set. Cognitive sub-processes were investigated with the Reaction Time Decomposition (RTD) method and the Wisconsin Card Sorting Test (WCST), at baseline, Week 4 and Week 12.
In executive function, i.e. set shifting tasks, sertindole reversed cognitive deficits significantly more than haloperidol. It was demonstrated that this atypical drug improved cognitive processing independently of motor function. Patients receiving sertindole markedly improved on the RTD task at Week 4 and continued to improve (although at a slower rate) at Week 12, those patients receiving haloperidol showed marked impairment at Week 4 with partial recovery by Week 12.
The study demonstrated two distinct processes of action on cognition between sertindole and haloperidol and the marked beneficial effects of sertindole, particularly in parameters that are regarded as schizophrenia-related cognitive disturbances.
比较塞汀多和氟哌啶醇对精神分裂症患者认知功能的影响。
在一项为期12周的试验中，40名随机接受治疗的患者中，34名（17名接受塞汀多治疗，17名接受氟哌啶醇治疗）被纳入分析组。在基线、第4周和第12周时，采用反应时间分解（RTD）法和威斯康星卡片分类测验（WCST）对认知子过程进行研究。
在执行功能，即定势转换任务方面，塞汀多比氟哌啶醇更能显著逆转认知缺陷。结果表明，这种非典型药物独立于运动功能改善认知加工。接受塞汀多治疗的患者在第4周时RTD任务显著改善，并在第12周时继续改善（尽管速度较慢），而接受氟哌啶醇治疗的患者在第4周时表现出明显受损，到第12周时部分恢复。
该研究证明了塞汀多和氟哌啶醇在认知作用上有两个不同的过程，以及塞汀多的显著有益作用，特别是在被视为与精神分裂症相关的认知障碍参数方面。
