Babiĭchuk V G
Ukr Biokhim Zh (1999). 2007 Jan-Feb;79(1):112-23.
The influence of extremal cryoeffects on the state of prooxidant and antioxidant systems in the blood serum and heart tissues was studied in young and old rats. It is shown that kinematic parameters of chemiluminescence after cold effects are less expressed in the blood serum of old animals than in young ones. The level of TBA-active products in the blood of young rats was lower than in old ones. After the 6th and 9th cold effect the content of TBA-active products in old animal appoaches such indices in young animals. Three weeks after the cold effects the content of TBA-active products in the myocardium of old rats corresponded to control indices, while in the young ones they were considerably lower. The fermentative link state was investigated in the antioxidant protection system. After the extremal cryoeffects glutathione reductase and glutathione peroxidase activity in old animals approaches its indices in intact rats, while catalase activity increases. Three weeks after cryoeffects one can observe a stable increase of fermentative activity of heart tissues both in old and young animals compared with the control that can evidence for the increase of the organism cold resistance.
研究了极端低温效应对年轻和老年大鼠血清及心脏组织中促氧化和抗氧化系统状态的影响。结果表明，低温作用后化学发光的动力学参数在老年动物血清中的表达低于年轻动物。年轻大鼠血液中TBA活性产物的水平低于老年大鼠。在第6次和第9次低温作用后，老年动物血液中TBA活性产物的含量接近年轻动物的此类指标。低温作用三周后，老年大鼠心肌中TBA活性产物的含量与对照指标相当，而年轻大鼠的含量则明显较低。对抗氧化保护系统中的发酵环节状态进行了研究。极端低温作用后，老年动物体内谷胱甘肽还原酶和谷胱甘肽过氧化物酶的活性接近正常大鼠的指标，而过氧化氢酶活性增加。低温作用三周后，与对照组相比，老年和年轻动物心脏组织的发酵活性均出现稳定增加，这可证明机体抗寒能力增强。
